Aging sustains the hypertrophy-associated elevation of apoptotic suppressor X-linked inhibitor of apoptosis protein (XIAP) in skeletal muscle during unloading.


This study tested the hypotheses that apoptotic suppressors: (a) increase during muscle overload, (b) decrease in response to unloading following hypertrophy, and (c) respond to unloading in an aging-dependent fashion. Following 14 days of stretch-induced overloading, the X-linked inhibitor of apoptosis protein (XIAP) was elevated by 140% and 116% in… (More)


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