Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

@article{Guela1998AgingRT,
  title={Aging renders the brain vulnerable to amyloid β-protein neurotoxicity},
  author={C. Guela and Chuang-Kuo Wu and D. Saroff and A. Lorenzo and M. Yuan and B. Yankner},
  journal={Nature Medicine},
  year={1998},
  volume={4},
  pages={827-831}
}
The formation of fibrillar deposits of amyloid β protein (Aβ) in the brain is a pathological hallmark of Alzheimer's disease1,2 (AD). A central question is whether Aβ plays a direct role in the neurodegenerative process in AD (refs. 3,4). The involvement of Aβ in the neurodegenerative process is suggested by the neurotoxicity of the fibrillar form of Aβ in vitro 5–11. However, mice transgenic for the Aβ precursor protein that develop amyloid deposits in the brain do not show the degree of… Expand
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