Aging-related inflammation in osteoarthritis.

  title={Aging-related inflammation in osteoarthritis.},
  author={Meredith A. Greene and Richard F. Loeser},
  journal={Osteoarthritis and cartilage},
  volume={23 11},
It is well accepted that aging is an important contributing factor to the development of osteoarthritis (OA). The mechanisms responsible appear to be multifactorial and may include an age-related pro-inflammatory state that has been termed "inflamm-aging." Age-related inflammation can be both systemic and local. Systemic inflammation can be promoted by aging changes in adipose tissue that result in increased production of cytokines such as interleukin (IL)-6 and tumor necrosis factor-α (TNF… CONTINUE READING
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