Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system.

  title={Aging-related deficits in orexin/hypocretin modulation of the septohippocampal cholinergic system.},
  author={Emily M. Stanley and Jim R Fadel},
  volume={66 5},
The medial septum (MS) of the basal forebrain contains cholinergic neurons that project to the hippocampus, support cognitive function, and are implicated in age-related cognitive decline. Hypothalamic orexin/hypocretin neurons innervate and modulate basal forebrain cholinergic neurons and provide direct inputs to the hippocampus. However, the precise role of orexin in modulating hippocampal cholinergic transmission--and how these interactions are altered in aging--is unknown. Here, orexin A… CONTINUE READING


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