Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance

@inproceedings{Zolla2015AgingrelatedAA,
  title={Aging-related anatomical and biochemical changes in lymphatic collectors impair lymph transport, fluid homeostasis, and pathogen clearance},
  author={Valerio Zolla and Irina Tsoy Nizamutdinova and Brian Scharf and Cristina C. Clement and Daisuke Maejima and Tony J. Akl and Takashi Nagai and Paola Luciani and Jean-Christophe Leroux and Cornelia Halin and Sabriya A. Stukes and Sangeeta Tiwari and Arturo Casadevall and William Robert Jacobs and David Entenberg and David C Zawieja and John S Condeelis and David Robert Fooksman and Anatoliy A. Gashev and Laura Santambrogio},
  booktitle={Aging cell},
  year={2015}
}
The role of lymphatic vessels is to transport fluid, soluble molecules, and immune cells to the draining lymph nodes. Here, we analyze how the aging process affects the functionality of the lymphatic collectors and the dynamics of lymph flow. Ultrastructural, biochemical, and proteomic analysis indicates a loss of matrix proteins, and smooth muscle cells in aged collectors resulting in a decrease in contraction frequency, systolic lymph flow velocity, and pumping activity, as measured in vivo… CONTINUE READING
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