Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models

@inproceedings{Dekker2017AgingRT,
  title={Aging rather than aneuploidy affects monoamine neurotransmitters in brain regions of Down syndrome mouse models},
  author={Alain D Dekker and Yannick Vermeiren and Christelle Albac and Eva Lana-Elola and Sheona Watson-Scales and Dorota Gibbins and Tony Aerts and Debby Van Dam and Elizabeth M. C. Fisher and Victor L. J. Tybulewicz and Marie-Claude Potier and Peter Paul De Deyn},
  booktitle={Neurobiology of Disease},
  year={2017}
}
Altered concentrations of monoamine neurotransmitters and metabolites have been repeatedly found in people with Down syndrome (DS, trisomy 21). Because of the limited availability of human post-mortem tissue, DS mouse models are of great interest to study these changes and the underlying neurobiological mechanisms. Although previous studies have shown the potential of Ts65Dn mice - the most widely used mouse model of DS - to model noradrenergic changes, a comprehensive monoaminergic… CONTINUE READING
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