Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.

@article{Yukata2014AgingPP,
  title={Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment.},
  author={Kiminori Yukata and Chao Xie and Tian-fang Li and Masahiko Takahata and Donna Hoak and Sirish Kondabolu and Xinping Zhang and Hani A Awad and Edward M. Schwarz and Christopher A. Beck and Jennifer H. Jonason and Regis J O'keefe},
  journal={Bone},
  year={2014},
  volume={62},
  pages={
          79-89
        }
}
A stabilized tibia fracture model was used in young (8-week old) and aged (1-year old) mice to define the relative bone regenerative potential and the relative responsiveness of the periosteal progenitor population with aging and PTH 1-34 (PTH) systemic therapy. Bone regeneration was assessed through gene expressions, radiographic imaging, histology/histomorphometry, and biomechanical testing. Radiographs and microCT showed increased calcified callus tissue and enhanced bone healing in young… CONTINUE READING

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