Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.

@article{Masson1997AgingOD,
  title={Aging of di-isopropyl-phosphorylated human butyrylcholinesterase.},
  author={Patrick Masson and Pierre-Louis Fortier and Claude Albaret and Marie Th{\'e}r{\`e}se Froment and Cynthia F. Bartels and Oksana Lockridge},
  journal={The Biochemical journal},
  year={1997},
  volume={327 ( Pt 2)},
  pages={601-7}
}
Organophosphate-inhibited cholinesterases can be reactivated by nucleophilic compounds. Sometimes phosphylated (phosphorylated or phosphonylated) cholinesterases become progressively refractory to reactivation; this can result from different reactions. The most frequent process, termed 'aging', involves the dealkylation of an alkoxy group on the phosphyl moiety through a carbocation mechanism. In attempting to determine the amino acid residues involved in the aging of butyrylcholinesterase… CONTINUE READING

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