Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels.

@article{Gangemi2005AgingIC,
  title={Aging is characterized by a profound reduction in anti-inflammatory lipoxin A4 levels.},
  author={Sebastiano Gangemi and Lea Pescara and Etrusca D'Urbano and Giorgio Basile and Vittorio Nicita-Mauro and Giovanni Dav{\'i} and M{\'a}rio Romano},
  journal={Experimental gerontology},
  year={2005},
  volume={40 7},
  pages={612-4}
}
Ongoing low-grade chronic inflammation represents a pathogenetic background for age-related diseases. In this report, we tested the hypothesis that endogenous anti-inflammatory mechanisms may become less efficient with age, resulting in increased susceptibility to inflammatory disorders. Using previously validated ELISA assays, we evaluated urinary levels of the anti-inflammatory, pro-resolution, arachidonic acid (AA) metabolite, lipoxin (LX)A(4) and of the pro-inflammatory cysteinyl… CONTINUE READING

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