Aging is associated with increased regulatory T-cell function

  title={Aging is associated with increased regulatory T-cell function},
  author={Sanjay Kumar Garg and Colin Delaney and Tomomi Toubai and Amiya Kumar Ghosh and Pavan Reddy and Ruma Banerjee and Raymond Yung},
  booktitle={Aging cell},
Regulatory T-cell (Treg, CD4(+) CD25(+)) dysfunction is suspected to play a key role in immune senescence and contributes to increased susceptibility to diseases with age by suppressing T-cell responses. FoxP3 is a master regulator of Treg function, and its expression is under control of several epigenetically labile promoters and enhancers. Demethylation of CpG sites within these regions is associated with increased FoxP3 expression and development of a suppressive phenotype. We examined… CONTINUE READING
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