Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential

@inproceedings{Dong2016AgingIA,
  title={Aging is associated with an expansion of CD49fhi mammary stem cells that show a decline in function and increased transformation potential},
  author={Qiaoxiang Dong and Hui Gao and Yuanshuo Shi and Fuchuang Zhang and Xiang Qun Gu and Anqi Wu and Danhan Wang and Yuanhong Chen and Abhik Bandyopadhyay and I J Yeh and Benjamin J. Daniel and Yidong Chen and Yi Zou and Vivienne L. Rebel and Christi A. Walter and Jian-xin Lu and Changjiang Huang and Lu-Zhe Sun},
  booktitle={Aging},
  year={2016}
}
Breast cancer incidence increases during aging, yet the mechanism of age-associated mammary tumorigenesis is unclear. Mammary stem cells are believed to play an important role in breast tumorigenesis, but how their function changes with age is unknown. We compared mammary epithelial cells isolated from young and old mammary glands of different cohorts of C57BL6/J and BALB/c mice, and our findings revealed that old mammary glands were characterized by increased basal cell pool comprised of… CONTINUE READING