Aging is accompanied by a progressive decrease of expression of the WRN gene in human blood mononuclear cells.


The WRN gene encodes DNA helicase participating in genome maintenance. We looked for associations of natural aging with expression and methylation of this gene in blood mononuclear cells and with its common polymorphisms. Analyses were performed in ethnically homogenous Polish Caucasians. The mean level of the WRN messenger RNA was significantly lower in… (More)
DOI: 10.1093/gerona/glq162


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