Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat.

@article{Asano2007AgingIM,
  title={Aging influences multiple indices of oxidative stress in the heart of the Fischer 344/NNia x Brown Norway/BiNia rat.},
  author={Shinichi Asano and Kevin M. Rice and Sunil K. Kakarla and Anjaiah Katta and Devashish H Desai and Ernest M. Walker and Paulette S Wehner and Eric Blough},
  journal={Redox report : communications in free radical research},
  year={2007},
  volume={12 4},
  pages={167-80}
}
We report the influence of aging on multiple markers of oxidative-nitrosative stress in the heart of adult (6-month), aged (30-month) and very aged (36-month) Fischer 344/NNiaHSd x Brown Norway/BiNia (F344/NXBN) rats. Compared to adult (6-month) hearts, indices of oxidative (superoxide anion [O2*-], 4-hydroxy-2-nonenal [4-HNE]) and nitrosative (protein nitrotyrosylation) stress were 34.1 +/- 28.1%, 186 +/- 28.1% and 94 +/- 5.8% higher, respectively, in 36-month hearts and these findings were… CONTINUE READING