Aging induced endoplasmic reticulum stress alters sleep and sleep homeostasis.

Abstract

Alterations in the quality, quantity, and architecture of baseline and recovery sleep have been shown to occur during aging. Sleep deprivation induces endoplasmic reticular (ER) stress and upregulates a protective signaling pathway termed the unfolded protein response. The effectiveness of the adaptive unfolded protein response is diminished by age… (More)
DOI: 10.1016/j.neurobiolaging.2013.12.005

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