Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse.

@article{Cao2005AgingIS,
  title={Aging increases stromal/osteoblastic cell-induced osteoclastogenesis and alters the osteoclast precursor pool in the mouse.},
  author={Jay J. Cao and Thomas J. Wronski and Urszula T. Iwaniec and Laura Phleger and Pam Kurimoto and Benjamin M. Boudignon and Bernard P. Halloran},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={2005},
  volume={20 9},
  pages={1659-68}
}
UNLABELLED Stromal/osteoblastic cell expression of RANKL and M-CSF regulates osteoclastogenesis. We show that aging is accompanied by increased RANKL and M-CSF expression, increased stromal/osteoblastic cell-induced osteoclastogenesis, and expansion of the osteoclast precursor pool. These changes correlate with age-related alterations in the relationship between osteoblasts and osteoclasts in cancellous bone. INTRODUCTION Bone mass is maintained through a balance between osteoblast and… CONTINUE READING

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