Aging in the lympho-hematopoietic stem cell compartment.

@article{Geiger2009AgingIT,
  title={Aging in the lympho-hematopoietic stem cell compartment.},
  author={Hartmut Geiger and K Lenhard Rudolph},
  journal={Trends in immunology},
  year={2009},
  volume={30 7},
  pages={
          360-5
        }
}
Cells of the immune system are progeny of a single primitive cell type, the hematopoietic stem cell (HSC). Aging in most strains of mice is associated with a reduction in HSC frequency and a reduction in HSC function. Aged HSCs demonstrate reduced differentiation toward the lymphoid lineage, and this might be a relevant factor influencing immunosenescence. The molecular mechanisms of HSC aging need to be determined in more detail, but current studies have identified, among others, a role for… CONTINUE READING
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