Aging in mouse and human systems: a comparative study.

  title={Aging in mouse and human systems: a comparative study.},
  author={Lloyd A. Demetrius},
  journal={Annals of the New York Academy of Sciences},
This article discusses the significance of mouse models as a basis for elucidating the aging process in humans. We identify certain parallels between mouse and human systems and review the theoretical and empirical support for the claim that the large divergence in the rate of aging between the two species resides in differences in the stability of their metabolic networks. We will show that these differences in metabolic stability have their origin in the different ecological constraints the… CONTINUE READING