Aging impairs smooth muscle-mediated regulation of aortic stiffness: a defect in shock absorption function?

@article{Gao2014AgingIS,
  title={Aging impairs smooth muscle-mediated regulation of aortic stiffness: a defect in shock absorption function?},
  author={Yuan Gao and Robert J. Saphirstein and Rina Yamin and B{\'e}la Suki and Kathleen G Morgan},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2014},
  volume={307 8},
  pages={H1252-61}
}
Increased aortic stiffness is an early and independent biomarker of cardiovascular disease. Here we tested the hypothesis that vascular smooth muscle cells (VSMCs) contribute significantly to aortic stiffness and investigated the mechanisms involved. The relative contributions of VSMCs, focal adhesions (FAs), and matrix to stiffness in mouse aorta preparations at optimal length and with confirmed VSMC viability were separated by the use of small-molecule inhibitors and activators. Using… CONTINUE READING

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