Aging impairs osteoblast differentiation of mesenchymal stem cells grown on titanium by favoring adipogenesis

@inproceedings{Abuna2016AgingIO,
  title={Aging impairs osteoblast differentiation of mesenchymal stem cells grown on titanium by favoring adipogenesis},
  author={Rodrigo P. F. Abuna and Camila Tami Stringhetta-Garcia and Leonardo Pimentel FIORI and Rita C{\'a}ssia Menegati Dornelles and Adalberto L Rosa and Marcio M Beloti},
  booktitle={Journal of applied oral science : revista FOB},
  year={2016}
}
OBJECTIVE We investigated the osteoblast and adipocyte differentiation of mesenchymal stem cells (MSCs) from young and aged rats cultured on Ti. MATERIAL AND METHODS Bone marrow MSCs derived from 1-month and 21-month rats were cultured on Ti discs under osteogenic conditions for periods of up to 21 days and osteoblast and adipocyte markers were evaluated. RESULTS Cell proliferation, alkaline phosphatase (ALP) activity, extracellular matrix mineralization and gene expression of RUNX2… CONTINUE READING
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