Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling.

@article{Simpson2010AgingFR,
  title={Aging fibroblasts resist phenotypic maturation because of impaired hyaluronan-dependent CD44/epidermal growth factor receptor signaling.},
  author={Russell M. L. Simpson and Alan Wells and David W Thomas and P. Stephens and Robert Steadman and Aled O Phillips},
  journal={The American journal of pathology},
  year={2010},
  volume={176 3},
  pages={1215-28}
}
Fibroblast differentiation into myofibroblasts is a key event during normal wound repair. We have previously demonstrated an age-related defect in this process associated with impaired synthesis of hyaluronan (HA) synthase (HAS) 2 but failed to prescribe its role in a mechanistic sense. Here we demonstrate that in addition to HAS2, there is loss of EGF receptor (EGF-R) in aged cells, and both are required for normal fibroblast functionality. Analysis of molecular events revealed that in young… CONTINUE READING
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