Aging enhances classical activation but mitigates alternative activation in the central nervous system.

@article{Lee2013AgingEC,
  title={Aging enhances classical activation but mitigates alternative activation in the central nervous system.},
  author={Daniel C. Lee and Claudia R. Ruiz and Lori Lebson and M L B Selenica and Justin Rizer and Jerry B Hunt and Rahil Rojiani and Patrick Reid and Sidharth Kammath and Kevin Nash and Chad A Dickey and Marcia L. Gordon and David Morgan},
  journal={Neurobiology of aging},
  year={2013},
  volume={34 6},
  pages={1610-20}
}
The roles of microglia and macrophages during neuroinflammation and neurodegenerative diseases remain controversial. To date, at least 2 activations states have been suggested, consisting of a classical response (M1) and the alternative response (M2). Identifying selective biomarkers of microglia that representative their functional activation states may help elucidate disease course and enable a better understanding of repair mechanisms. Two cocktails containing either tumor necrosis factor… CONTINUE READING

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