Aging effects on the BDNF mRNA and TrkB mRNA expression of the hippocampus in different durations of stress.

@article{Shao2010AgingEO,
  title={Aging effects on the BDNF mRNA and TrkB mRNA expression of the hippocampus in different durations of stress.},
  author={Shu-hong Shao and S. Shi and Z. Li and Ming-Shan Zhao and Shu-yang Xie and Fang Pan},
  journal={The Chinese journal of physiology},
  year={2010},
  volume={53 5},
  pages={285-93}
}
Brain-derived neurotrophins factor (BDNF) belongs to the neurotrophins family which acts on neuronal survival and growth and has been associated with cognition process. TrkB is the primary signal transduction receptor for BDNF. In the present study, hippocampal BDNF and TrkB mRNA were detected by RT-PCR in 2- and 22-month rats, respectively, which were exposed to different durations of mild stress protocol of 8-day, 21-day and 28-day chronic unpredictable mild stress (CUMS). Observation of… CONTINUE READING

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