Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids.

@article{Drummond2008AgingDA,
  title={Aging differentially affects human skeletal muscle microRNA expression at rest and after an anabolic stimulus of resistance exercise and essential amino acids.},
  author={Micah J Drummond and John J McCarthy and Christopher S Fry and Karyn A Esser and Blake B Rasmussen},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2008},
  volume={295 6},
  pages={E1333-40}
}
Sarcopenia, skeletal muscle loss during aging, is associated with increased falls, fractures, morbidity, and loss of independence. MicroRNAs (miRNAs) are novel posttranscriptional regulators. The role of miRNAs in cell size regulation after an anabolic stimulus in human skeletal muscle is unknown. We hypothesized that aging would be associated with a differential expression of skeletal muscle primary miRNA (pri-miRNA) and mature miRNA (miR). To test this hypothesis, we used real-time PCR and… CONTINUE READING

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