Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire.

@article{Johnson2002AgingdependentEO,
  title={Aging-dependent exclusion of antigen-inexperienced cells from the peripheral B cell repertoire.},
  author={Sara A. Johnson and Stephen J. Rozzo and John C Cambier},
  journal={Journal of immunology},
  year={2002},
  volume={168 10},
  pages={
          5014-23
        }
}
Aging is accompanied by greatly reduced B cell production in the bone marrow, yet peripheral B cell numbers do not decline. We hypothesize that this may reflect filling of the peripheral pool with B cells that are long-lived as a consequence of specificity for, and chronic stimulation by, environmental Ags. To begin to explore this possibility, we analyzed the effects of aging on B cell population dynamics in the anti-H2(k/b) 3-83 mu-delta Ig-transgenic mouse. We predicted that, because they… CONTINUE READING
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