Aging decreases the capacity of human skin to produce vitamin D3.

  title={Aging decreases the capacity of human skin to produce vitamin D3.},
  author={Ja MacLaughlin and Michael F Holick},
  journal={The Journal of clinical investigation},
  volume={76 4},
An evaluation of surgically obtained skin (age range, 8-92 yr) revealed that there is an age-dependent decrease in the epidermal concentrations of provitamin D3 (7-dehydrocholesterol). To ascertain that aging indeed decreased the capacity of human skin to produce vitamin D3, some of the skin samples were exposed to ultraviolet radiation and the content of previtamin D3 was determined in the epidermis and dermis. The epidermis in the young and older subjects was the major site for the formation… Expand

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  • 1995
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