Aging decreases rebound synaptic excitation produced by removal of NMDA receptor block in the striatum

 The influence of age on NMDA receptor-mediated excitatory postsynaptic potentials (EPSPs) was characterized in striatal in vitro brain slices using intracellular recording techniques. All slices were bathed in bicuculline methiodide (20 μM) to isolate EPSPs from intrinsic inhibition and Mg2+ was omitted from the artificial cerebral spinal fluid to reduce… CONTINUE READING