Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling.

@article{Miranda2012AgingBM,
  title={Aging brain microenvironment decreases hippocampal neurogenesis through Wnt-mediated survivin signaling.},
  author={Carlos J. Miranda and Lyndsey Braun and Yuying Jiang and Mark E. Hester and Ling Zhang and Matthew Riolo and Haijuan Wang and Meghan Rao and Rachel A. Altura and Brian K Kaspar},
  journal={Aging cell},
  year={2012},
  volume={11 3},
  pages={542-52}
}
Accumulating evidence suggests that adult hippocampal neurogenesis relies on the controlled and continued proliferation of neural progenitor cells (NPCs). With age, neurogenesis decreases through mechanisms that remain unclear but are believed to involve changes in the NPC microenvironment. Here, we provide evidence that NPC proliferation in the adult brain is in part regulated by astrocytes via Wnt signaling and that this cellular cross-talk is modified in the aging brain, leading to decreased… CONTINUE READING
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