Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair

@article{Clarke2003AgingAW,
  title={Aging as war between chemical and biochemical processes: Protein methylation and the recognition of age-damaged proteins for repair},
  author={Steven G. Clarke},
  journal={Ageing Research Reviews},
  year={2003},
  volume={2},
  pages={263-285}
}
Deamidated, isomerized, and racemized aspartyl and asparaginyl residues represent a significant part of the spontaneous damage to proteins that results from the aging process. The accumulation of these altered residues can lead to the loss of protein function and the consequent loss of cellular function. However, almost all cells in nature contain a methyltransferase that can recognize the major damaged form of the L-isoaspartyl residue, and some of these enzymes can also recognize the… CONTINUE READING
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