Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid.

@article{Shan2016AgingAA,
  title={Aging as a Precipitating Factor in Chronic Restraint Stress-Induced Tau Aggregation Pathology, and the Protective Effects of Rosmarinic Acid.},
  author={Ye Shan and Dan-Dan Wang and Yu-Xia Xu and Chu Wang and Lan Cao and Yun-sheng Liu and Cui-qing Zhu},
  journal={Journal of Alzheimer's disease : JAD},
  year={2016},
  volume={49 3},
  pages={829-44}
}
Stress is an important risk factor of Alzheimer's disease (AD). It has been evidenced that stress could induce tau phosphorylation and increase tau insolubility in brain; however, little is known about the interactional effect of stress with aging on tauopathy. Therefore, we explored the effects of aging on stress-induced tauopathy and the potential mechanism in mouse model of chronic restraint stress (CRS). Here we found that in general, the level of phosphorylated tau (P-tau) was higher in… CONTINUE READING