Aging and venous thromboembolism influence the pharmacodynamics of the anti-factor Xa and anti-thrombin activities of a low molecular weight heparin (nadroparin).

@article{Mismetti1998AgingAV,
  title={Aging and venous thromboembolism influence the pharmacodynamics of the anti-factor Xa and anti-thrombin activities of a low molecular weight heparin (nadroparin).},
  author={Patrick Mismetti and S Laporte-simitsidis and Chantal Navarro and Pi{\`e}rre Si{\'e} and P d'Az{\'e}mar and Jos{\'e} Necciari and Jean Pierre Duret and Christine Gaud and Herv{\'e} D{\'e}cousus and Bernard Boneu},
  journal={Thrombosis and haemostasis},
  year={1998},
  volume={79 6},
  pages={1162-5}
}
Venous thromboembolism may be efficiently treated by one single daily administration of a high dose of low molecular weight heparin (LMWH). The present study investigates if the physiological deterioration of renal function associated with normal aging or the presence of an acute venous thromboembolism influences the pharmacodynamic pattern of the anti-factor Xa and anti-thrombin activities. Three groups of 12 subjects were investigated. The first 2 groups were composed of healthy volunteers… CONTINUE READING

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