• DOI:10.1097/01.hjh.0000239293.40507.2a
• Corpus ID: 40503159

Aging and vascular responses to flavanol-rich cocoa

@article{Fisher2006AgingAV,
  title={Aging and vascular responses to flavanol-rich cocoa},
  author={Naomi D.L. Fisher and Norman K. Hollenberg},
  journal={Journal of Hypertension},
  year={2006},
  volume={24},
  pages={1575–1580}
}

• N. Fisher, N. Hollenberg
• Published 1 August 2006
• Medicine
• Journal of Hypertension

Objectives Strong evidence has secured aging as a powerful predictor of both cardiovascular risk and endothelial dysfunction, yet specific treatment is not available. We tested the hypothesis that vascular responsiveness to flavanol-rich cocoa increases with advancing age. We have previously shown that flavanol-rich cocoa induced peripheral vasodilation, improving endothelial function via a nitric oxide (NO)-dependent mechanism. Methods We studied blood pressure and peripheral arterial responses to several days of cocoa in 15 young (< 50 years) and 19 older (> 50) healthy subjects. Results The nitric oxide synthase (NOS) inhibitor Nω-nitro-L-arginine-methyl-ester (L-NAME) induced significant pressor responses following cocoa administration only among the older subjects: systolic blood pressure (SBP) rose 13 ± 4 mmHg, diastolic blood pressure (DBP) 6 ± 2 mmHg (P = 0.008 and 0.047, respectively); SBP was significantly higher in the older subjects (P < 0.05). Flow-mediated vasodilation, measured by tonometry in the finger, was enhanced with flavanol-rich cocoa in both groups, but significantly more so among the old (P = 0.01). Finally, basal pulse wave amplitude (PWA) followed a similar pattern. Four to six days of flavanol-rich cocoa caused a rise in PWA in both groups. At peak vasodilation following acute cocoa intake on the final day, both groups showed a further, significant rise in PWA. The response in the older subjects was more robust; P < 0.05. L-NAME significantly reversed dilation in both groups. Conclusions Flavanol-rich cocoa enhanced several measures of endothelial function to a greater degree among older than younger healthy subjects. Our data suggest that the NO-dependent vascular effects of flavanol-rich cocoa may be greater among older people, in whom endothelial function is more disturbed.