Aging and the rise of somatic cancer-associated mutations in normal tissues

@article{Risques2018AgingAT,
  title={Aging and the rise of somatic cancer-associated mutations in normal tissues},
  author={R. A. Risques and S. Kennedy},
  journal={PLoS Genetics},
  year={2018},
  volume={14}
}
DNA mutations are inevitable. Despite proficient DNA repair mechanisms, somatic cells accumulate mutations during development and aging, generating cells with different genotypes within the same individual, a phenomenon known as somatic mosaicism. While the existence of somatic mosaicism has long been recognized, in the last five years, advances in sequencing have provided unprecedented resolution to characterize the extent and nature of somatic genetic variation. Collectively, these new… Expand
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