Aging and the renin-angiotensin system.

  title={Aging and the renin-angiotensin system.},
  author={Sara Conti and Paola Cassis and Ariela Benigni},
  volume={60 4},
A ngiotensin II (Ang II), the dominant effector molecule of the renin-angiotensin system (RAS), exerts its effects on binding of 2 pharmacologically distinct rhodopsin-like G protein–associated receptors, the type 1 and the type 2 (AT 1 and AT 2) receptors. 1 Human cells express a single AT 1 receptor, whereas 2 isoforms, AT 1A and AT 1B with 95% of amino acid sequence identity and similar affinities for Ang II, are present in rodents. The AT 1A receptor, the closest murine homo-logue to the… CONTINUE READING