Aging and the human pituitary gland.

  title={Aging and the human pituitary gland.},
  author={Takehisa Sano and Kalman T. Kovacs and Bernd Walter Scheithauer and William Francis Young},
  journal={Mayo Clinic proceedings},
  volume={68 10},
Pituitary glands obtained at autopsy from 41 men (90 to 97 years old) and 45 women (90 to 98 years old) were studied histologically and immunohistochemically to determine the age-related alterations. Pituitaries from patients 30 to 39 years old (48 cases) and 60 to 89 years old (187 cases) were also studied and served as controls. Interstitial, perivascular fibrosis was seen in 88% of the aged adenohypophyses and, although significantly more intense than that in those of the fourth decade of… CONTINUE READING