Aging and the UPR(ER)

@article{Taylor2016AgingAT,
  title={Aging and the UPR(ER)},
  author={Rebecca Clare Taylor},
  journal={Brain Research},
  year={2016},
  volume={1648},
  pages={588-593}
}
The aging process is characterized by tissue decline and the onset of age-associated disease. It is not, however, immutable, and aging can be modulated by various genetic and environmental means. One of the interventions that can modulate lifespan is the activation of cellular stress responses, including the unfolded protein response in the endoplasmic reticulum (UPRER). The ability to activate the UPRER declines with age, while its constitutive activation can extend longevity. It also plays… CONTINUE READING
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