Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats

@article{Siddharth2017AgingAS,
  title={Aging and sarcopenia associate with specific interactions between gut microbes, serum biomarkers and host physiology in rats},
  author={Jay Siddharth and Anirikh Chakrabarti and Alice Pann{\'e}rec and Sonia Karaz and Delphine Morin-Rivron and Mojgan Masoodi and Jerome N. Feige and Scott James Parkinson},
  journal={Aging (Albany NY)},
  year={2017},
  volume={9},
  pages={1698 - 1714}
}
The microbiome has been demonstrated to play an integral role in the maintenance of many aspects of health that are also associated with aging. In order to identify areas of potential exploration and intervention, we simultaneously characterized age-related alterations in gut microbiome, muscle physiology and serum proteomic and lipidomic profiles in aged rats to define an integrated signature of the aging phenotype. We demonstrate that aging skews the composition of the gut microbiome, in… Expand
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References

SHOWING 1-10 OF 51 REFERENCES
Aging and serum MCP-1 are associated with gut microbiome composition in a murine model
TLDR
Gut microbiome composition is associated with age and the pro-inflammatory marker, serum MCP-1, in mice and indicates that the gut microbiome may play a modulating role in age-related inflammatory processes. Expand
Gut microbiota and aging
TLDR
Detailed analyses have separated the microbiota into groups associated with age, long-term residential care, habitual diet, and degree of retention of a core microbiome, which provide a framework for analyzing microbiota-health associations and developing microbiota-based health surveillance for older adults. Expand
The Microbiome and Musculoskeletal Conditions of Aging: A Review of Evidence for Impact and Potential Therapeutics.
TLDR
Evidence to date on the role of the microbiome and the highly prevalent age-related disorders of osteoporosis, osteoarthritis, gout, rheumatoid arthritis, sarcopenia, and frailty are discussed. Expand
The Microbiota and Microbiome in Aging: Potential Implications in Health and Age‐Related Diseases
TLDR
Manipulation of the microbiota and microbiome of older adults holds promise as an innovative strategy to influence the development of comorbidities associated with aging. Expand
Microbial shifts in the aging mouse gut
TLDR
Differences in functions related to host nutrition and drug pharmacology vary in an age-dependent manner, suggesting that the availability and timing of essential functions may differ significantly with age and frailty. Expand
Gut microbiota composition correlates with diet and health in the elderly
TLDR
The data support a relationship between diet, microbiota and health status, and indicate a role for diet-driven microbiota alterations in varying rates of health decline upon ageing. Expand
Aging and the human gut microbiota—from correlation to causality
TLDR
Given that increases in life expectancy will likely result in an increase in the elderly population worldwide, analysis of the contribution of the microbiota to healthy aging assumes greater significance and age-related spatio-temporal variations in the microbiota are best viewed within an ecological- evolutionary framework. Expand
Functional metagenomic profiling of intestinal microbiome in extreme ageing
TLDR
The data emphasize the relationship between intestinal bacteria and human metabolism, by detailing the modifications in the gut microbiota as a consequence of and/or promoter of the physiological changes occurring in the human host upon ageing. Expand
The intestinal microbiome and skeletal fitness: Connecting bugs and bones.
TLDR
A broader interpretation of this question reveals many mechanisms whereby the microbiome may affect bone cells, and as mechanistic interactions of the microbiome and skeletal system are revealed within and without the immune system, novel strategies to optimize skeletal fitness may emerge. Expand
Succession of microbial consortia in the developing infant gut microbiome
TLDR
This study revealed that seemingly chaotic shifts in the microbiome are associated with life events; however, additional experiments ought to be conducted to assess how different infants respond to similar life events. Expand
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5
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