Aging and protein oxidative damage.

  title={Aging and protein oxidative damage.},
  author={Shikha Agarwal and Rajindar S. Sohal},
  journal={Mechanisms of ageing and development},
  volume={75 1},
The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucose-6-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidative damage. Membrane protein -SH content and activities of these enzymes decreased with age and were correlated with the life expectancy or physiological age rather than the… CONTINUE READING

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