Aging and muscle fiber type alter K+ channel contributions to the myogenic response in skeletal muscle arterioles.

@article{Kang2009AgingAM,
  title={Aging and muscle fiber type alter K+ channel contributions to the myogenic response in skeletal muscle arterioles.},
  author={Lori S. Kang and Sejeong Kim and James M. Dominguez and Amy L. Sindler and Gregory M. Dick and Judy M Muller-Delp},
  journal={Journal of applied physiology},
  year={2009},
  volume={107 2},
  pages={389-98}
}
Aging diminishes myogenic tone in arterioles from skeletal muscle. Recent evidence indicates that both large-conductance Ca2+-activated (BKCa) and voltage-dependent (KV) K+ channels mediate negative feedback control of the myogenic response. Thus we tested the hypothesis that aging increases the contributions of KV and BKCa channels to myogenic regulation of vascular tone. Because myogenic responsiveness differs between oxidative and glycolytic muscles, we predicted that KV and BKCa channel… CONTINUE READING
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