Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression.

@article{Li1998AgingAF,
  title={Aging and fasting regulation of leptin and hypothalamic neuropeptide Y gene expression.},
  author={Hua Li and Michael K. Matheny and Nihal T{\"u}mer and Philip J. Scarpace},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={1998},
  volume={275 3},
  pages={E405-E411}
}
To investigate the role of aging on the fasting-induced suppression of leptin gene expression and increase in hypothalamic neuropeptide Y (NPY) gene expression, we fasted or fed ad libitum male F-344xBN rats aged 3, 24, and 31 mo for 2 days. We examined leptin mRNA levels in retroperitoneal, inguinal, and epididymal white adipose tissue (WAT); serum leptin levels; and NPY mRNA levels in the hypothalamus. We found that leptin mRNA levels were increased from 3 to 24 mo and leveled off between 24… CONTINUE READING