Aging and defense against generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA.

@article{Mikkelsen2009AgingAD,
  title={Aging and defense against generation of 8-oxo-7,8-dihydro-2'-deoxyguanosine in DNA.},
  author={Lone Mikkelsen and Karol Bialkowski and Lotte Risom and Mille L\ohr and Steffen Loft and Peter M\oller},
  journal={Free radical biology & medicine},
  year={2009},
  volume={47 5},
  pages={608-15}
}
The imbalance between the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in DNA and the efficiency of cellular systems of DNA protection and repair is considered an important factor in the age-dependent development of cancer. This study investigated the relationship between oxidatively damaged DNA and the activity of the DNA repair system and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxodGTPase) activity in liver and lung tissue from mice at 10-100… CONTINUE READING