Aging and defective healing, adverse remodeling, and blunted post-conditioning in the reperfused wounded heart.

Abstract

ptimal healing of the wounded heart is critical for the reservation of structural and functional integrity of the umping chambers and for survival with a favorable outome. This is especially important in elderly patients, in hom myocardial infarction (MI) is prevalent and in whom efective healing may promote adverse remodeling, thereby eopardizing outcome. ealing post-MI. Acute MI triggers a host of biochemial, molecular, and cellular changes that lead to the highly omplex, dynamic, and concurrent processes of healing, epair, and remodeling in an attempt to repair structural amage and preserve left ventricular (LV) function (1).

DOI: 10.1016/j.jacc.2007.12.027

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@article{Jugdutt2008AgingAD, title={Aging and defective healing, adverse remodeling, and blunted post-conditioning in the reperfused wounded heart.}, author={Bodh I . Jugdutt and Anwar Jelani}, journal={Journal of the American College of Cardiology}, year={2008}, volume={51 14}, pages={1399-403} }