Aging and Wound Healing

  title={Aging and Wound Healing},
  author={Ankush Gosain and Luisa A. DiPietro},
  journal={World Journal of Surgery},
Impaired wound healing in the elderly presents a major clinical and economic problem. With the aging population growing in both number and percentage, the importance of understanding the mechanisms underlying age-related impairments in healing is increased. Normal skin exhibits characteristic changes with age that have implications for wound healing. Additionally, the process of wound healing is altered in aged individuals. Although historically healing in the aged was considered defective… 
Wound Healing in the Elderly
The elderly have increased rates of infection and wound dehiscence, decreases in wound strength, and slower healing times, primarily caused by reductions in re-epithelialization, angiogenesis, macrophage infiltration, and collagen deposition.
Aging influences wound healing in patients with chronic lower extremity wounds treated in a specialized wound care center
It was clearly showed that aging affects chronic wound healing negatively, and the effect of aging on the frequency of wound closure of chronic wounds became clinically apparent after age 60.
Wound Healing in the Golden Agers: What We Know and the Possible Way Ahead
Understanding the complex pathobiology of cellular senescence and wound healing process is required to develop focused therapy for these “problem wounds” in the elderly.
The Elderly Burn Patient
The purpose of this chapter is to discuss the unique epidemiology, pathophysiology, treatment, and outcomes of burns in the elderly.
A review of the effects of ageing on skin integrity and wound healing.
The anatomy of the skin and the effects of ageing on the tissues are discussed and some guidance on skin assessment and the basics of skin care is offered.
Factors Affecting Wound Healing
The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition, which may lead to therapeutics that improve wound healing and resolve impaired wounds.
Stress, Aging, andWound Healing
This chapter will expand on this by reviewing the human literature on stress and wound healing, and by highlighting the phenomenological and mechanistic similarities of this literature with the findings from aging research.
Exercise, Obesity, and Cutaneous Wound Healing: Evidence from Rodent and Human Studies.
Exercise is a relatively low-cost intervention strategy which may be able to be used clinically to prevent or treat impairments in the wound-healing process, and has been shown to speed healing in both aged and obese mice and in older adults.
Models of wound healing: an emphasis on clinical studies
  • K. Wilhelm, D. Wilhelm, S. Bielfeldt
  • Medicine, Biology
    Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging
  • 2017
The healing of wounds has always provided challenges for the medical community whether chronic or acute and the use of human models offers the best opportunity to understand the factors that influence wound healing as well as to evaluate efficacy of treatments applied to wounds.


Effect of age on wound healing in healthy human beings.
In healthy humans, aging leads to delayed epithelialization, and no effect of age on collagen synthesis was noted, although accumulation of wound noncollagenous protein was decreased, which may impair the mechanical properties of scarring in aged human beings.
Growth Factors and Chronic Wounds: The Need to Understand the Microenvironment
  • V. Falanga
  • Medicine, Biology
    The Journal of dermatology
  • 1992
It is hypothesize that the chronic wound microenvironment is generally non‐conducive to cell growth, and that this may prevent a truly successful use of topical growth factors in chronic wounds.
The role of nutrition in prevention and healing of pressure ulcers.
  • D. Thomas
  • Medicine
    Clinics in geriatric medicine
  • 1997
Decrease in capillary growth during aging
Age-related alterations in the inflammatory response to dermal injury.
The data demonstrate age-related shifts in both macrophage and T cell infiltration into wounds, alterations in chemokine content, and a concurrent decline in wound Macrophage phagocytic function, which may contribute to the delayed repair response of aging.
Systemic drugs and nutritional aspects of wound healing.
Comorbidity and the Elderly Trauma Patient
An awareness of the importance of preexisting medical conditions and a coordinated, directed approach to the management of the injuries and the concomitant diseases leads to the most effective care in the elderly.
Structural changes in aging human skin.
The architecture of the elastic fiber framework in the papillary dermis of skin protected from the sun is reviewed; aging changes that occur are similar to, but less severe than, those in sun-exposed areas.
Tensile Properties and Morphology of Healing Wounds in Young and old rats
The findings indicate that the faster healing observed in young rats is, at least to some extent, due to a better organization of the collagenous fibre meshwork.
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta.
TGF-beta is a potent pharmacologic agent that can accelerate wound healing in rats and is accompanied by an increased influx of mononuclear cells and fibroblasts and by marked increases in collagen deposition at the site of application of TGF- beta.