Aging and Insulin Resistance: Just Say iNOS

  title={Aging and Insulin Resistance: Just Say iNOS},
  author={Joseph L Evans and Ira D Goldfine},
The ubiquitous presence of insulin resistance cannot be understated. First brought to light by Himsworth and Kerr (1) in 1939, insulin resistance, defined as a subnormal response to a given dose of insulin, was ushered into prime time by Gerald Reaven (2), where it has remained at center stage. Insulin resistance is a major feature of type 2 diabetes (2). Insulin resistance is also associated with obesity, essential hypertension, dyslipidemia, nonalcoholic fatty liver disease, obstructive sleep… CONTINUE READING
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