Aging alters the activity of 5'-deiodinase in the adenohypophysis, thyroid gland, and liver of the male rat.

@article{Donda1989AgingAT,
  title={Aging alters the activity of 5'-deiodinase in the adenohypophysis, thyroid gland, and liver of the male rat.},
  author={Alena Donda and Th. Lemarchand-B{\'e}raud},
  journal={Endocrinology},
  year={1989},
  volume={124 3},
  pages={
          1305-9
        }
}
Aging is characterized by a decreased secretion of thyroid hormones in rats associated with unchanged plasma TSH suggestive of impairments in the hypothalamo-pituitary-thyroid axis. Since it is known that pituitary T3 is more determinant on TSH secretion than plasma T3, we measured in young (4 months) and old (26 months) male rats the concentration of T3 in the anterior pituitary gland and found that it was similar in young and old animals despite the low circulating levels of thyroid hormones… CONTINUE READING
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