Aging alterations in whole-brain networks during adulthood mapped with the minimum spanning tree indices: The interplay of density, connectivity cost and life-time trajectory

@article{Otte2015AgingAI,
  title={Aging alterations in whole-brain networks during adulthood mapped with the minimum spanning tree indices: The interplay of density, connectivity cost and life-time trajectory},
  author={Willem M. Otte and Eric van Diessen and Subhadip Paul and Rajiv Ramaswamy and V. P. Subramanyam Rallabandi and Cornelis J. Stam and Prasun K. Roy},
  journal={NeuroImage},
  year={2015},
  volume={109},
  pages={171-89}
}
The organizational network changes in the human brain across the lifespan have been mapped using functional and structural connectivity data. Brain network changes provide valuable insights into the processes underlying senescence. Nonetheless, the altered network density in the elderly severely compromises the usefulness of network analysis to study the aging brain. We successfully circumvented this problem by focusing on the critical structural network backbone, using a robust tree… CONTINUE READING
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