Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears.

@article{Fernandez2015AgingAN,
  title={Aging after noise exposure: acceleration of cochlear synaptopathy in "recovered" ears.},
  author={Katharine A Fernandez and Penelope W C Jeffers and Kumud Lall and M Charles Liberman and Sharon G. Kujawa},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2015},
  volume={35 19},
  pages={7509-20}
}
Cochlear synaptic loss, rather than hair cell death, is the earliest sign of damage in both noise- and age-related hearing impairment (Kujawa and Liberman, 2009; Sergeyenko et al., 2013). Here, we compare cochlear aging after two types of noise exposure: one producing permanent synaptic damage without hair cell loss and another producing neither synaptopathy nor hair cell loss. Adult mice were exposed (8-16 kHz, 100 or 91 dB SPL for 2 h) and then evaluated from 1 h to ∼ 20 months after exposure… CONTINUE READING
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