Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues.

@article{TabibianKeissar2016AgingAB,
  title={Aging affects B-cell antigen receptor repertoire diversity in primary and secondary lymphoid tissues.},
  author={Hilla Tabibian-Keissar and Lena Hazanov and Ginette Schiby and Noemie Rosenthal and Aviya Shapira Rakovsky and Miri Michaeli and Gitit Lavy Shahaf and Yishai Pickman and Kinneret Rosenblatt and Doron Melamed and Deborah Dunn-Walters and Ramit Mehr and Iris Barshack},
  journal={European journal of immunology},
  year={2016},
  volume={46 2},
  pages={480-92}
}
The elderly immune system is characterized by reduced responses to infections and vaccines, and an increase in the incidence of autoimmune diseases and cancer. Age-related deficits in the immune system may be caused by peripheral homeostatic pressures that limit bone marrow B-cell production or migration to the peripheral lymphoid tissues. Studies of… CONTINUE READING