Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice.

@article{Ivic2017AgingInducedMO,
  title={Aging-Induced Modulation of Pituitary Adenylate Cyclase-Activating Peptide- and Vasoactive Intestinal Peptide-Induced Vasomotor Responses in the Arteries of Mice.},
  author={Ivan Ivic and Margit Solym{\'a}r and Balazs Daniel Fulop and Hitoshi Hashimoto and Gabor X Toth and Andrea Tamas and Tam{\'a}s Juh{\'a}sz and A. E. Koller and Dora Reglodi},
  journal={Journal of vascular research},
  year={2017},
  volume={54 6},
  pages={
          359-366
        }
}
Pituitary adenylate cyclase-activating peptide (PACAP; 1-38 and 1-27) and vasoactive intestinal peptide (VIP) are related neuropeptides of the secretin/glucagon family. Overlapping signaling through G-protein-coupled receptors mediates their vasomotor activity. We previously showed that PACAP deficiency (PACAP-KO) shifts the mechanisms of vascular response and maintains arterial relaxation through the VIP backup mechanism and (mainly) its VPAC1R, but their age-dependent modulation is still… CONTINUE READING