Aging Fits the Disease Criteria of the International Classification of Diseases

  title={Aging Fits the Disease Criteria of the International Classification of Diseases},
  author={Daria A. Khaltourina and Yuri Matveyev and Aleksey G. Alekseev and Franco Cortese and Anca Ioviţă},
  journal={Mechanisms of Ageing and Development},
Cellular immune phenotypes and worsening scores of frailty-associated parameters over an 18-month period in the very old.
Higher frequencies of B-cells and late-differentiated CD8+ T-cells at 18 months from baseline were associated with ADL impairment that had worsened over the preceding 18 months, suggesting certain adaptive immune, but not innate immune, parameters are associated with a worsened ADL in the very old.
Gerosuppressive and Senolytic Nutrients
  • J. Nehlin
  • Medicine
    Healthy Ageing and Longevity
  • 2021
To strengthen the knowledge that natural compounds present in the diet, when given at the right time, at theright dose and in combination, could extend the duration of health span and the overall lifespan, a summary of senotherapeutic biomolecules acting as senolytics and gerosuppressors will be presented.
The Etiology and Pathophysiology Genesis of Benign Prostatic Hyperplasia and Prostate Cancer: A New Perspective
This prostate ageing degeneration hypothesis encompasses the testosterone-vascular-inflamm-ageing triad, along with the cell biology regulation of amyloidosis and autophagy within an evolutionary tumorigenesis microenvironment.
Targeting aging mechanisms: pharmacological perspectives
Considerations Regarding Public Use of Longevity Interventions
It is urged that not all interventions will be beneficial for each individual and therefore it is imperative that individuals track their own aging rates to assess healthy aging interventions and propose how to use such approaches to test interventions in the general population.
Altered expression profile of long non-coding RNAs during heart aging in mice
The results imply that the differentially expressed lncRNAs may regulate the development of heart aging, as demonstrated by the results demonstrated that the heart function in aged mice was impaired relative to young ones.
2′-Fucosyllactose Ameliorates Oxidative Stress Damage in d-Galactose-Induced Aging Mice by Regulating Gut Microbiota and AMPK/SIRT1/FOXO1 Pathway
2′-FL significantly reduced oxidative stress damage and inflammation in the intestines of aging mice, potentially by regulating the sirtuin1 (SIRT1)-related and nuclear factor E2-related factor 2 (Nrf2) pathways.


Recognizing Degenerative Aging as a Treatable Medical Condition: Methodology and Policy
The devising of clinically applicable and scientifically grounded definitions and criteria for the multifactorial degenerative aging process (or “senility” using the existing ICD category), underlying major aging-related diseases, as well as for the safety and effectiveness of interventions against it are examined.
Classifying aging as a disease in the context of ICD-11
The arguments for classifying aging as a disease in the context of the upcoming World Health Organization’s 11th International Statistical Classification of Diseases and Related Health Problems (ICD-11), expected to be finalized in 2018 are explored.
To help aging populations, classify organismal senescence
A systematic and comprehensive approach to the classification and staging of organismal senescence and aging-related diseases at the organ and tissue levels is described in order to guide policy and practice and enable appropriate interventions and clinical guidance, systems, resources, and infrastructure.
Biomarkers of Aging: From Function to Molecular Biology
The current knowledge of putative biomarkers is presented, focusing on their application to the major physiological mechanisms affected by the aging process including physical capability, nutritional status, body composition, endocrine and immune function.
Aging and liver disease.
The effect of aging on clinical liver disease is assessed with references to preclinical models when relevant to pathogenesis and future studies are needed to understand more about the molecular mechanism of aging and contribute to the development of a noble treatment strategy that can block the progression of aging-induced liver diseases.
Aging: Molecular Pathways and Implications on the Cardiovascular System
It is possible to draw a common pathway unifying aging to cardiovascular diseases, and the central point of this process, senescence, can be the target for new therapies, which may result in the healthspan matching the lifespan.
Cardiac aging: from molecular mechanisms to significance in human health and disease.
The understanding of the molecular mechanisms of cardiac aging may support the potential clinical application of several "anti-aging" strategies that treat CVDs and improve healthy cardiac aging.
The intersection between aging and cardiovascular disease.
Some of the key genes involved in regulating lifespan and health span, including sirtuins, AMP-activated protein kinase, mammalian target of rapamycin, and insulin-like growth factor 1 and their roles regulating cardiovascular health are provided.