Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria

@inproceedings{Rottenberg2000AgingET,
  title={Aging Enhances the Activation of the Permeability Transition Pore in Mitochondria},
  author={Hagai Rottenberg and Michael Mather},
  booktitle={Biochemical and biophysical research communications},
  year={2000}
}
Aging is associated with mitochondrial dysfunction in several tissues. However, it is not known how the observed mitochondrial dysfunction is related to aging-associated tissue degeneration. We have shown previously that the activation of the permeability transition pore (PTP), which is believed to play a critical role in cell necrosis and apoptosis, is enhanced in spleen lymphocytes from old mice. Here we show that the threshold for calcium-induced, cyclosporin-sensitive, calcium release was… CONTINUE READING

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